AI Article Synopsis
- - The study aimed to identify immune-related genes linked to kidney papillary cell carcinoma (pRCC) by analyzing RNA sequencing data and clinical info from the TCGA database, along with a list of immune genes from Immport.
- - Researchers identified 2,468 differentially expressed genes, including 183 immune-related genes, and pinpointed four key hub genes through Cox and LASSO analyses, establishing their prognostic significance with solid statistical backing (Kaplan-Meier and ROC analyses).
- - Results indicated that patients in the high-risk group had a greater proportion of B cells, higher levels of immune-related gene expression, and a more favorable response to immunotherapy.
Article Abstract
Immune-related genes are important factors in tumor progression. The main aim of this study was to identify the immune-related genes in kidney papillary cell carcinoma (pRCC) patients. We downloaded RNAseq data and clinical information of pRCC patients from the TCGA database and retrieved the immune-related genes list from Immport. From the data, we mined out 2,468 differential expression genes (DEGs) and 183 immune-related DEGs. Four hub DEGs (, , , and ) were identified after conducting Cox analysis and LASSO analysis. Moreover, the prognostic value of the signature based on four hub DEGs was verified using Kaplan-Meier analysis (P = 0.0041 in the training set and p = 0.021 in the test set) and ROC analysis (AUC: 0.957 in 1 year, 0.965 in 2 years, and 0.901 in 3 years in the training set, and 0.963 in 1 year, 0.898 in 2 years, and 0.742 in 3 years in the test set). Furthermore, we found that the high-risk score group had a higher percentage of B cells in the immune component, a higher expression of immune-related genes (, , , and ), and a better immunotherapy response.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8215362 | PMC |
| http://dx.doi.org/10.3389/fonc.2021.670047 | DOI Listing |
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