A simple chiroptical solution for the absolute stereochemical determination for asymmetric phosphorus V stereocenters is presented. Strong coordination of the phosphorus oxide with the Zn-metallo center of the racemic host Zn-MAPOL leads to an induced axial chirality of the host, yielding a strong ECCD signal. A mnemonic is proposed to correlate the asymmetry of the guest molecule with the observed ECCD signal.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179206 | PMC |
| http://dx.doi.org/10.1039/d0sc02940h | DOI Listing |
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