AI Article Synopsis
- The shape of nanomaterials affects how they interact biologically, but there's a need for better methods to create non-spherical biocompatible particles.
- Researchers combined a technique called 'living' crystallisation-driven self-assembly with a type of polymer known as poly(2-oxazoline)s, which is known for its biocompatibility and 'stealth' properties.
- The result was the successful creation of POx nanorods in water, with a promising ability to avoid immune detection and maintain longer blood circulation times, indicating their potential as advanced drug delivery systems.
Article Abstract
The morphology of nanomaterials critically influences their biological interactions. However, there is currently a lack of robust methods for preparing non-spherical particles from biocompatible materials. Here, we combine 'living' crystallisation-driven self-assembly (CDSA), a seeded growth method that enables the preparation of rod-like polymer nanoparticles, with poly(2-oxazoline)s (POx), a polymer class that exhibits 'stealth' behaviour and excellent biocompatibility. For the first time, the 'living' CDSA process was carried out in pure water, resulting in POx nanorods with lengths ranging from ∼60 to 635 nm. and study revealed low immune cell association and encouraging blood circulation times, but little difference in the behaviour of POx nanorods of different length. The stealth behaviour observed highlights the promising potential of POx nanorods as a next generation stealth drug delivery platform.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171341 | PMC |
| http://dx.doi.org/10.1039/d1sc00938a | DOI Listing |
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