An original multi-cooperative catalytic approach was developed by combining metal-ligand cooperation and Lewis acid activation. The [(SCS)Pd] complex featuring a non-innocent indenediide-based ligand was found to be a very efficient and versatile catalyst for the Conia-ene reaction, when associated with Mg(OTf). The reaction operates at low catalytic loadings under mild conditions with HFIP as a co-solvent. It works with a variety of substrates, including those bearing internal alkynes. It displays complete 5- 6- regio-selectivity. In addition, except for the highly congested Bu-substituent, the reaction occurs with high stereo-selectivity, making it synthetically useful and complementary to known catalysts.
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| http://dx.doi.org/10.1039/d0sc05036a | DOI Listing |
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