AI Article Synopsis
- The study aimed to assess the characteristics, management, and outcomes of hospitalized patients with Clostridioides difficile infection (CDI) treated with fidaxomicin compared to other therapies.
- Of the participants, a significant percentage were immunocompromised (39.1%) and had severe (59.2%) or recurrent (36.4%) CDI; fidaxomicin treatment showed a high clinical cure rate of 92.2% and a low recurrence rate of 16.3% after 3 months.
- The findings suggest that fidaxomicin is an effective and well-tolerated treatment for CDI, even among high-risk patients, with very few adverse events reported and no related deaths.
Article Abstract
Objective: To describe the characteristics, management and outcomes of hospitalised patients with infection (CDI) treated with and without fidaxomicin.
Methods: This prospective, multicentre, observational study (DAFNE) enrolled hospitalised patients with CDI, including 294 patients treated with fidaxomicin (outcomes recorded over a 3-month period) and 150 patients treated with other CDI therapies during three 1-month periods. The primary endpoint was baseline and CDI characteristics of fidaxomicin-treated patients.
Results: At baseline, the fidaxomicin-treated population included immunocompromised patients (39.1%) and patients with severe (59.2%) and recurrent (36.4%) CDI. Fidaxomicin was associated with a high rate of clinical cure (92.2%) and low CDI recurrence (16.3% within 3 months). Clinical cure rates were ≥90% in patients aged ≥65 years, those receiving concomitant antibiotics and those with prior or severe CDI. There were 121/296 (40.9%) patients with adverse events (AEs), 5.4% with fidaxomicin-related AEs and 1.0% with serious fidaxomicin-related AEs. No fidaxomicin-related deaths were reported.
Conclusions: Fidaxomicin is an effective and well-tolerated CDI treatment in a real-world setting in France, which included patients at high risk of adverse outcomes.Trial registration: Description of the use of fidaxomicin in hospitalised patients with documented infection and the management of these patients (DAFNE), NCT02214771, www.ClinicalTrials.gov.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236878 | PMC |
| http://dx.doi.org/10.1177/03000605211021278 | DOI Listing |
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