Parkinson's disease (PD), known since ancient times as paralysis agitans, was studied and described by James Parkinson in 1817 in his work "An Essay on the Shaking Palsy". Fifty years later, Charcot and his students delved into the disease, naming it as we know it today, as well as defining the classic disease and its variants. One of these students, Arthur Dutil, addressed patients' abnormal eye movements. Nowadays, it is known that the differential diagnosis of PD is relevant for prognosis, treatment and research, and, despite the advances in the area, it remains largely clinical. The relevance of the eye movement exam has grown along with the history of PD and it has proved to be an excellent tool for the differential diagnosis of parkinsonism. Additionally, it can become a support to identify different types of genetic PD and be useful for improving early recognition of cognitive decline in patients with PD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9394552 | PMC |
| http://dx.doi.org/10.1590/0004-282X-ANP-2020-0406 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Using Machine Learning to Diagnose Autism Based on Eye Tracking Technology.
Diagnostics (Basel)
December 2024
Computer Science Department, Yarmouk University, Irbid 21163, Jordan.
One of the key challenges in autism is early diagnosis. Early diagnosis leads to early interventions that improve the condition and not worsen autism in the future. Currently, autism diagnoses are based on monitoring by a doctor or specialist after the child reaches a certain age exceeding three years after the parents observe the child's abnormal behavior.
View Article and Find Full Text PDFPatient-derived cornea organoid model to study metabolomic characterization of rare disease: aniridia-associated keratopathy.
BMC Ophthalmol
January 2025
Izmir Biomedicine and Genome Center, 35340, Izmir, Türkiye.
Background: Aniridia is a rare panocular disease caused by gene mutation in the PAX6, which is essential for eye development. Aniridia is inherited in an autosomal dominant manner, but its phenotype can vary significantly among individuals with the same mutation. Animal models, such as drosophila, zebrafish, and rodents, have been used to study aniridia through Pax6 deletions.
View Article and Find Full Text PDFEstablishing normal interocular symmetry range for macular optical coherence tomography parameters in healthy children.
Eye (Lond)
January 2025
Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Objective: The study aimed to evaluate the interocular symmetry of macular sublayer thickness among healthy children aged 6-12 years.
Methods: The Shiraz Pediatric Eye Study included 500 randomly selected children who underwent SD-OCT of the macula and optical biometry using the IOLMaster-500. Exclusion criteria involved ocular abnormalities or axial lengths outside the 21.
Is rapid eye movement sleep behavior disorder a marker of Parkinson's disease severity?
Parkinsonism Relat Disord
December 2024
Movement Disorders Unit, Neurology Service, Department of Clinical Medicine, Federal University of Minas Gerais, Av Pasteur 89/1107, 30150-290, Belo Horizonte, MG, Brazil. Electronic address:
Background: Parkinson's disease (PD) is characterized by motor and non-motor features. There are several proposed clinical markers to define disease severity. However, if rapid eye movement sleep behavior disorder (RBD) is associated with worse prognosis of both motor and non-motor findings in PD is unknown.
View Article and Find Full Text PDFAutomated quantitative pupillometry as a predictor for transtentorial brain herniation in patients with malignant acute ischemic stroke.
PLoS One
January 2025
Department of Convergence of Healthcare and Medicine, Ajou University Graduate School of Medicine, Suwon, South Korea.
Brain herniation can be a life-threatening condition, resulting in poor prognosis and higher fatality rates. We examined whether quantitative characteristics of sequential pupillary light reflex (PLR) could serve as biomarkers for identifying brain herniation in fatal acute stroke cases with anterior circulation involvement admitted to neurological intensive care unit (Neuro-ICU). Automatic pupillometer assessed PLR automatically every 4-6 hours, measuring eight specific features: NPi (Neurological pupil index) score, initial resting and constriction pupil size, constriction change, constriction velocity, constriction latency, and dilation velocity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!