AI Article Synopsis
- The study found that pregnant rats consuming 15% alcohol instead of water experienced impaired learning and reduced brain enzyme activity, suggesting brain oxygen deficiency during fetal development.
- The synthetic opioid peptide dalargin was injected during crucial developmental stages and helped mitigate the negative effects of alcohol on brain function and cellular respiration.
- The researchers explored potential mechanisms by which dalargin exerted its protective effects against alcohol-induced brain damage.
Article Abstract
In the experiments on the progeny of ethanol-exposed rats it was shown that consumption of 15% alcohol instead of water during pregnancy resulted in the worsening of shuttlebox avoidance learning and decrease in succinate dehydrogenase activity in the visual and sensorimotor cortex. These data are indicative of cerebral hypoxia during embryogenesis. The injection of synthetic opioid peptide dalargin during critical periods of development (at the end of embryogenesis and early ontogeny) prevented partially the disturbances of higher nervous activity and tissue breathing which were induced by alcohol intoxication. Possible mechanisms of positive dalargin effect are discussed.
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