Objective: To determine the associations between matrix metalloproteinase-2 (MMP-2, encoded by the gene) 1306C/T and 735C/T polymorphisms and first and recurrent ischemic stroke in a Chinese population.
Methods: Patients with first and recurrent ischemic stroke were included. Serum MMP-2 was measured, and 1306C/T and 735C/T polymorphisms were detected. The associations between 1306C/T and 735C/T polymorphisms and first and recurrent ischemic stroke were analyzed.
Results: Serum MMP-2 in patients with first and recurrent ischemic stroke was significantly higher compared with controls, and patients with recurrent ischemic stroke had higher MMP-2 than those with first ischemic stroke. The frequency of the CC genotype and C allele of 735C/T was highest in patients with recurrent ischemic stroke, followed by patients with first ischemic stroke, and controls. Conversely, the genotype and allele of 1306C/T did not significantly differ between groups. The CC genotype of 735C/T was independently associated with first and recurrent ischemic stroke (odds ratios = 1.45 and 1.64, respectively), as was the C allele of 735C/T (odds ratios = 1.68 and 1.77, respectively).
Conclusions: The CC genotype and C allele of 735C/T were associated with first and recurrent ischemic stroke in a Chinese population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236801 | PMC |
| http://dx.doi.org/10.1177/03000605211022967 | DOI Listing |
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