AI Article Synopsis

  • Pre-existing conditions like obesity and metabolic diseases worsen COVID-19 outcomes, emphasizing the link between chronic disorders and unhealthy diets, known as the Western Diet.* -
  • In a study using Syrian hamsters, a continuous high-fat high-sugar diet was shown to result in worse COVID-19 symptoms, including weight loss, lung damage, and prolonged viral presence in the body.* -
  • The findings suggest that the hamster model can be useful for researching dietary modifications and therapies to potentially improve COVID-19 outcomes in patients with metabolic diseases.*

Article Abstract

Pre-existing comorbidities such as obesity or metabolic diseases can adversely affect the clinical outcome of COVID-19. Chronic metabolic disorders are globally on the rise and often a consequence of an unhealthy diet, referred to as a Western Diet. For the first time in the Syrian hamster model, we demonstrate the detrimental impact of a continuous high-fat high-sugar diet on COVID-19 outcome. We observed increased weight loss and lung pathology, such as exudate, vasculitis, hemorrhage, fibrin, and edema, delayed viral clearance and functional lung recovery, and prolonged viral shedding. This was accompanied by an increased trend of systemic IL-10 and IL-6, as well as a dysregulated serum lipid response dominated by polyunsaturated fatty acid-containing phosphatidylethanolamine, recapitulating cytokine and lipid responses associated with severe human COVID-19. Our data support the hamster model for testing restrictive or targeted diets and immunomodulatory therapies to mediate the adverse effects of metabolic disease on COVID-19.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219093PMC
http://dx.doi.org/10.1101/2021.06.17.448814DOI Listing

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