This study was carried out to determine the presence of polymorphisms in genes affecting litter size. The SNPs in bone morphogenetic protein receptor type 1B (), bone morphogenetic protein 15 (), and growth differentiation factor 9 () genes were detected in 60 uniparous and 60 multiparous ewes from Ramlıç and Dağlıç breeds. The ewes are maintained in nine public herds at the breeding station of the Afyonkarahisar Sheep and Goats Breeders' Association and lambed in two consecutive breeding seasons. PCR and DNA sequencing analyses were conducted, and 36, 4, and 11 SNPs in Ramlıç and 40, 3, and 11 SNPs in Dağlıç were detected in , , and genes, respectively. A total of 16 SNPs in Ramlıç and 10 SNPs in Dağlıç breeds for three genes were found to be significant ( ). The resulting analyses showed that four SNPs (g.49496G>A, c.1658A>C, c.2037C>T, c.2053C>T) of the gene and one deletion mutation (c.28_30delCTT) in the gene of the Ramlıç breed as well as five SNPs (c.1487C>A, c.2492C>T, c.2523G>A, c.2880A>G, and c.2763G>A) of the gene of the Dağlıç breed have significant positive regression coefficients in the desired direction of the rare allele. The observed mutations have potential to be used as genetic markers in the selection of prolific animals for both breeds.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209503 | PMC |
| http://dx.doi.org/10.5194/aab-64-223-2021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Generation and propagation of high fecundity gene edited fine wool sheep by CRISPR/Cas9.
Sci Rep
January 2025
Key Laboratory of Genetics, Breeding and Reproduction of Grass-Feeding Livestock, Key Laboratory of Animal Biotechnology of Xinjiang, Ministry of Agriculture(MOA), Urumqi, 830026, Xinjiang, China.
CRISPR/Cas9 technology has been widely utilized to enhance productive performance, increase disease resistance and generate medical models in livestock. The FecB allele in sheep is a mutation in the BMPRIB gene, recognized as the first major gene responsible for the high fecundity trait in sheep, leading to an increased ovulation rate in ewe. In this study, we employed CRISPR/Cas9-mediated homologous-directed repair (HDR) to introduce a defined point mutation (c.
View Article and Find Full Text PDFScreening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome.
BMC Vet Res
January 2025
Department of Veterinary Clinical Sciences, Clinic for Swine, Justus-Liebig-University, Frankfurter Strasse 112, D-35392, Giessen, Germany.
Background: The recently identified swine inflammation and necrosis syndrome (SINS) affects tail, ears, teats, coronary bands, claws and heels of affected individuals. The primarily endogenous syndrome is based on vasculitis, thrombosis, and intimal proliferation, involving defence cells, interleukins, chemokines, and acute phase proteins and accompanied by alterations in clinical chemistry, metabolome, and liver transcriptome. The complexity of metabolic alterations and the influence of the boar led to hypothesize a polygenic architecture of SINS.
View Article and Find Full Text PDFPotential Candidate Genes Associated with Litter Size in Goats: A Review.
Animals (Basel)
January 2025
School of Agricultural Science and Engineering, Liaocheng University, Liaocheng 252000, China.
Article Synopsis
- This review focuses on genetic markers that influence litter size in goats, a critical trait for enhancing productivity in small ruminant farming.
- Goats are important for economic stability across various regions, but their reproductive efficiency is often low, impacting farm profitability.
- Recent genetic research has identified several key genes connected to reproductive traits, which could help improve selective breeding programs and boost productivity by increasing litter sizes.
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring.
Ecotoxicol Environ Saf
January 2025
School of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, China; Department of Reproductive Medicine, the 1st affiliated hospital, Jiangxi Medical College, Nanchang University; Jiangxi Key Laboratory of Reproductive Health, Nanchang 330006, China; HuanKui College, Nanchang University, Nanchang 330031, China; Chongqing Research Institute of Nanchang University, Nanchang University, Nanchang 330006, China. Electronic address:
The impact of micro/nano plastics (MPs/NPs) on human health is a significant area of research. Studies on the effects of maternal exposure to microplastics (MPs) on the fertility in offspring have been conducted, but the damage caused by nanoplastics (NPs) remains ambiguous. In this study, pregnant Kunming mice were exposed to 30 mg/kg/day PS-NPs from 0.
View Article and Find Full Text PDFPhosphate addition intensifies the increase in NO emission under nitrogen deposition in wet meadows of the Qinghai-Tibet Plateau.
Front Microbiol
December 2024
College of Forestry, Gansu Agricultural University, Lanzhou, China.
Alpine wet meadows are known as NO sinks due to nitrogen (N) limitation. However, phosphate addition and N deposition can modulate this limitation, and little is known about their combinative effects on NO emission from the Qinghai-Tibet Plateau in wet meadows. This study used natural wet meadow as the control treatment (CK) and conducted experiments with N (CONH addition, N15), P (NaHPO addition, P15), and their combinations (CONH and NaHPO addition, N15P15) to investigate how N and P supplementation affected soil NO emissions in wet meadow of QTP.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!