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| http://dx.doi.org/10.21037/acs-2020-cfmcs-200 | DOI Listing |
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Single-organelle visualization tracking natural glycosaminoglycans within mitochondria-lysosome crosstalk for inflammatory homeostasis.
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School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; National Glycoengineering Research Center, Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University, Qingdao, Shandong 266237, China. Electronic address:
Glycosaminoglycans (GAGs), as natural products with diverse biological activities, play a significant role in regulating inflammatory homeostasis. Nevertheless, the mechanism underlying their intracellular anti-inflammatory properties remains unclear. Herein, we propose a single-organelle visualization tracking framework, leveraging an advanced fluorescent imaging technology combined with labeling methods to dynamically trace the subcellular regulatory mechanisms of GAGs in eliminating inflammatory markers, such as reactive oxygen species (ROS).
View Article and Find Full Text PDFThe B Chromosome of Pseudococcus viburni: A Selfish Chromosome that Exploits Whole-Genome Meiotic Drive.
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Meiosis is generally a fair process: each chromosome has a 50% chance of being included into each gamete. However, meiosis can become aberrant with some chromosomes having a higher chance of making it into gametes than others. Yet, why and how such systems evolve remains unclear.
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Department of Chemistry, University of Botswana, Botswana Private bag UB, Gaborone, 00704, Botswana.
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View Article and Find Full Text PDFWe demonstrate a widely spaced, stabilized, and self-referenced opto-electronic oscillator driven electro-optic modulator based optical frequency comb. Using an ultra-stable Fabry-Perot etalon as a stable reference, we simultaneously stabilize a CW laser and generate a low noise and stable RF oscillation used to drive an electro-optic comb. In such a manner, the Fabry-Perot etalon pins both the carrier-envelope-offset frequency ( ) and the repetition rate of the comb in place ( ), eliminating the need for an external RF oscillator.
View Article and Find Full Text PDFWho drives weight stigma? A multinational exploration of clustering characteristics behind weight bias against preconception, pregnant, and postpartum women.
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Health and Social Care Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Background: Weight bias is a global health challenge and community members are endorsed as the most common source of weight bias. The nature of weight biases specifically against preconception, pregnant, and postpartum (PPP) women from the perspective of community members is not known, especially in terms of cross-cultural trends. We investigated the magnitude of explicit and implicit weight bias and profiles of characteristics associated with harbouring weight bias.
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