Although simultaneous open surgery for synchronous gastric and colon cancer has been reported frequently to date, total laparoscopic resection has been documented rarely. A 63-year-old male patient who presented with complaints of abdominal pain and constipation was diagnosed with synchronous gastric and sigmoid colon cancer. Simultaneous total laparoscopic distal gastrectomy (Roux-en-Y anastomosis and D2 lymph node dissection) and anterior resection were performed with a total of five ports. Total operation time was 310 min. and estimated blood loss was 175 mL. Histopathological examination result was reported as well-differentiated adenocarcinoma for the stomach and moderately differentiated adenocarcinoma for the colon. Staging result was Stage IIA (pT3N0M0, American Joint Committee on Cancer (AJCC) 8th Edition) for both cancers. The patient received postoperative adjuvant chemotherapy. He remains under follow-up at 21 months without any recurrence. With the improved techniques and increased experience in minimally invasive surgery, combined laparoscopic curative resection can be safely performed for gastric and colon cancer.
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http://dx.doi.org/10.7759/cureus.15692 | DOI Listing |
PLoS One
January 2025
Cardiovascular Outcomes Research Laboratories (CORELAB), University of California, Los Angeles, Los Angeles, CA, United States of America.
Purpose: Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have been noted to face increased cancer incidence. Yet, the impact of concomitant renal dysfunction on acute outcomes following elective surgery for cancer remains to be elucidated.
Methods: All adult hospitalizations entailing elective resection for lung, esophageal, gastric, pancreatic, hepatic, or colon cancer were identified in the 2016-2020 National Inpatient Sample.
ACS Nano
January 2025
Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China.
Manganese ions (Mn) are an immune activator that enhances the activation of both cGAS and STING proteins. The STING signaling activation and subsequential immune responses are predominantly associated with endoplasmic reticulum (ER). Therefore, ER targeting of Mn in the subcellular compartments would promote the activation of STING signaling pathways.
View Article and Find Full Text PDFJ Neuroendocrinol
January 2025
Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Colonic neuroendocrine tumors (NETs), excluding rectal NETs, are often described as relatively common and aggressive, with inferior median survival compared with other gastrointestinal (GI) primary sites. However, epidemiological databases may conflate well-differentiated NETs with poorly differentiated neuroendocrine carcinomas (NECs), leading to a lack of precise data on the prevalence, clinical behavior, and prognosis of well-differentiated colonic NETs. We analyzed a large institutional database to identify patients with well-differentiated NETs originating in the colon, excluding rectal NETs.
View Article and Find Full Text PDFDiscov Oncol
January 2025
Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
Early diagnosis and disease management based on risk stratification have a very positive impact on colon adenocarcinoma (COAD) prognosis. It is of positive significance to further explore risk stratification of COAD patients and identify predictive molecular biomarkers. PANoptosis is defined as a form of inflammatory cell death regulated by PANoptosome, with common features of pyroptosis, apoptosis and necroptosis.
View Article and Find Full Text PDFClin Exp Med
January 2025
Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
The role of metabolic reprogramming of the tumor immune microenvironment in cancer development and immune escape has increasingly attracted attention. However, the predictive value of differences in metabolism-immune microenvironment on the prognosis of colon cancer (CC) and the response to immunotherapy have not been elucidated. The aim of this study was to investigate changes in metabolism and immune profile of CC and to identify a reliable signature for predicting prognosis and therapeutic response.
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