Objective: This article reviews the pharmacology, safety, efficacy, and clinical importance of abametapir 0.74% (Xeglyze) for the treatment of head lice.
Data Sources: From 2020 to May 2021, a systematic review of the MEDLINE and EMBASE databases was conducted using the terms , , , and . Bibliographies, Food and Drug Administration (FDA) drug package inserts, and ClinicalTrials.gov were searched for further information.
Study Selection And Data Extraction: All relevant full-text articles in English were considered for inclusion, with a final article date range of 1999 to 2020.
Data Synthesis: Abametapir chelates heavy metal cations and inhibits metalloproteinases critical to louse ova development, hatching, and adult survival. In phase II, abametapir had direct ovicidal activity inhibiting 100% of treated louse eggs from hatching, compared with 64% in the vehicle-treated group. In two identical phase III clinical trials, subjects treated with a single 10-minute application of abametapir had greater treatment success compared with vehicle-treated subjects, with 81.1% success versus 50.9% in study 1 ( = 0.001) and 81.8% versus 47.2% in study 2 ( < 0.001). Abametapir was well tolerated, with only mild adverse effects.
Relevance To Patient Care And Clinical Practice: Abametapir is a newly FDA-approved, single-application treatment for head lice in patients aged 6 months and older. This review highlights the safety and efficacy of abametapir in the treatment of head lice.
Conclusions: In the wake of increasing widespread resistance to first-line treatment options, abametapir offers a safe and effective new treatment option for head lice infestations.
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| http://dx.doi.org/10.1177/10600280211027968 | DOI Listing |
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