Objective: Female urethral stricture is a rare, but often underrecognized, cause of voiding dysfunction in females. Vaginal free graft urethroplasty has been shown to have good efficacy and durability in treating urethral stricture, though accessible descriptions of technique are not widely available. Accordingly, we set out to describe and demonstrate our technique for vaginal mucosal free graft dorsal onlay urethroplasty.
Materials And Methods: A fifty-one year old female with long-standing history of voiding dysfunction and incomplete emptying presented to our urology clinic, and was diagnosed with urethral stricture. Following evaluation to ensure adequate vaginal mucosal tissue, treatment with vaginal graft urethroplasty was offered. Tenets for success in performing vaginal free graft urethroplasty include adequate dorsal urethral dissection and mobilization, incision of entire length of stricture, removal of underlying fibromuscular tissue from graft, and tension-free anastomosis of graft to urethra. Appropriate selection of vaginal graft harvest site is key to avoid excessive narrowing of the vagina.
Results: In this patient, vaginal free graft urethroplasty provided a successful and durable treatment of her urethral stricture. Vaginal free graft urethroplasty is an approachable and reproducible technique for treating urethral stricture in a female, while avoiding the morbidity associated with buccal graft harvest.
Conclusion: This video provides a step-by-step description of technique for performing vaginal free graft dorsal onlay urethroplasty to treat urethral stricture in a female.
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http://dx.doi.org/10.1016/j.urology.2021.06.004 | DOI Listing |
Ann Surg
January 2025
Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Aim: To validate the prognostic value of the PAncreatic NeoAdjuvant MAssachusetts (PANAMA)-score and to determine its predictive ability for survival benefit derived from adjuvant treatment in patients after resection of pancreatic ductal adenocarcinoma (PDAC) following neoadjuvant FOLFIRINOX.
Background: The PANAMA-score was developed to guide prognostication in patients after neoadjuvant therapy and resection for PDAC. As this score focuses on the risk for residual disease after resection, it might also be able to select patients who benefit from adjuvant after neoadjuvant therapy.
Indian J Urol
January 2025
Department of Urology and Renal Transplant, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Introduction: Pain at the buccal mucosal graft (BMG) harvest site in the immediate postoperative period is common and delays resumption of oral intake. This study compares the time for resumption of pain-free solid and liquid diets and postoperative pain scores at harvest site following the administration of inferior-alveolar nerve-block plus buccal-nerve block (IANB + BNB) versus placebo. We hypothesize that the intervention could decrease pain and aid in early food intake.
View Article and Find Full Text PDFChem Sci
January 2025
Department Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, School of Polymer Science and Engineering, Qingdao University of Science & Technology Qingdao 266042 P. R. China
Multi-resonance thermally activated delayed fluorescence (MR-TADF) emitters have been actively employed in high-resolution solution-processed organic light emitting diodes (OLEDs) due to their excellent color purity. Nonetheless, they are always confronted with intrinsic slow spin flip of triplet excitons, impeding the electroluminescence properties, especially in non-sensitized OLEDs. Herein, we constructed intramolecular charge transfer (ICT) assisted MR-TADF emitters by grafting donor-acceptor-type moieties with a - or -substitution as a pendant on an organoboron multi-resonance core.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Immunology, University Hospital Zurich (USZ), Zurich, Switzerland.
Background: Donor-derived cell-free DNA (dd-cfDNA) is a promising non-invasive biomarker for detecting graft injury in solid organ transplant recipients. Elevated dd-cfDNA levels are strongly associated with rejection and graft injury, especially antibody-mediated rejection (ABMR). While donor-specific antibodies (dnDSA) are crucial in ABMR, the relationship between dd-cfDNA levels and dnDSA features, such as DSA category, MFI and HLA target loci, remains unclear.
View Article and Find Full Text PDFCell Mol Biol Lett
January 2025
Clinical Research Center, Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, 201800, China.
Background: Circular (circ)RNAs have emerged as crucial contributors to cancer progression. Nonetheless, the expression regulation, biological functions, and underlying mechanisms of circRNAs in mediating hepatocellular carcinoma (HCC) progression remain insufficiently elucidated.
Methods: We identified circUCK2(2,3) through circRNA sequencing, RT-PCR, and Sanger sequencing.
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