Polymorphism in miRNA target sites of and ring complex influences expression of CEP genes and favors tumorigenesis in glioma.

The present study was designed to screen the genetic polymorphisms and expression profiling of and genes in brain tumor patients. The amplification refractory mutation system PCR technique (ARMS-PCR) was used for mutation analysis using 300 blood samples of brain tumor patients and 300 overtly healthy controls. For expression analysis, 150 brain tumor tissue samples along with adjacent uninvolved/normal tissues (controls) were collected. A significantly higher frequency of the mutant genotype of the single nucleotide polymorphism (rs2169757) and single nucleotide polymorphisms (rs9809619 and rs13060247) was observed in patients versus overtly healthy controls. The authors' results showed highly significant deregulation of (p < 0.0001) and (p < 0.0001) in glioma/meningioma tumor tissues versus adjacent normal tissue. The present study showed that variations in and genes were associated with an increased risk of brain tumor.