AI Article Synopsis
- * The study focuses on Claudin-14 (CLDN14), revealing its significant role in advancing colorectal cancer, including promoting cell growth, migration, and invasion.
- * Findings suggest that CLDN14 activates the PI3K/AKT/mTOR signaling pathway, indicating potential new approaches for managing and predicting outcomes in colorectal cancer patients.
Article Abstract
Colorectal cancer is the third leading cancer in the world in terms of incidence and mortality. The role of differentially expressed Claudin-14 (CLDN14) in CRC has not been reported. We observed that CLDN14 was associated with the progression of CRC. Our functional studies have shown that CLDN14 promoted the proliferation of CRC cells. In addition, CLDN14 also increased the migration and invasion of CRC cells. In vivo experiments also showed that CLDN14 promoted the growth of colorectal cancer via the PI3K/AKT/mTOR. In summary, our research suggests that CLDN14 promotes the progression of colorectal cancer. Our findings may provide new strategies for clinical management and patient prognosis of CRC.
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| http://dx.doi.org/10.4149/neo_2021_210210N203 | DOI Listing |
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