We describe the synthesis, photophysical properties, and photodynamic activity of a methemoglobin (metHb) wrapped covalently by human serum albumins (HSAs) incorporating protoporphyrin IX (PPIX): a metHb-HSA -PPIX cluster. The metHb core catalyzes H O disproportionation to generate O in tumor tissue. The HSA -PPIX shell acts as a photosensitizer for O formation. The metHb-HSA -PPIX cluster acts as a dual functional protein drug for photodynamic therapy.
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