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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273632 | PMC |
| http://dx.doi.org/10.3350/cmh.2021.0178 | DOI Listing |
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[Noninvasive Imaging Test to Assess Liver Fibrosis: Vibration-controlled Transient Elastography].
Korean J Gastroenterol
November 2024
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Liver fibrosis refers to the formation of scar tissue in the liver when inflammation persists over a long period. Assessing liver fibrosis is crucial for predicting the prognosis of chronic liver disease and managing patients with these conditions. Although a liver biopsy remains the gold standard for assessing liver fibrosis, it is limited by its invasive nature.
View Article and Find Full Text PDFTwice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype.
N Engl J Med
December 2024
From Guy's Severe Asthma Centre, Guy's and St. Thomas' NHS Foundation Trust, and the School of Immunology and Microbial Sciences, King's College London (David J. Jackson), Barts Health NHS Trust (P.E.P.), and GSK (L.J., N.B., S.S., P.H.), London, and the Oxford Respiratory NIHR Biomedical Research Centre, Nuffield Department of Clinical Medicine, University of Oxford, Oxford (I.D.P.) - all in the United Kingdom; National Jewish Health, Denver (M.E.W.); the University of Wisconsin-Madison, Madison (Daniel J. Jackson); the University of Cincinnati College of Medicine and Bernstein Clinical Research Center, Cincinnati (D.B.); Clinical Research Center, Respiratory Medicine, IKF Pneumologie Mainz, Mainz, and Thoraxklinik Heidelberg, Heidelberg - both in Germany (S.K.); State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Joint International Research Laboratory of Respiratory Health, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (R.C.); Fukushima Medical University, Fukushima, Japan (J.S.); Hospital Vithas Xanit Internacional, Málaga, Spain (G.L.M.); Centrum Medyczne Lucyna Andrzej Dymek, Strzelce Opolskie, Poland (L.D.); and GSK, Collegeville, PA (D.S.).
Background: Depemokimab is an ultra-long-acting biologic therapy with enhanced binding affinity for interleukin-5 that may enable effective 6-month dosing intervals.
Methods: In these phase 3A, randomized, placebo-controlled replicate trials, we evaluated the efficacy and safety of depemokimab in patients with severe asthma and an eosinophilic phenotype characterized by a high eosinophil count (≥300 cells per microliter in the previous 12 months or ≥150 cells per microliter at screening) and a history of exacerbations despite the receipt of medium- or high-dose inhaled glucocorticoids. Patients were randomly assigned in a 2:1 ratio to receive either depemokimab (at a dose of 100 mg subcutaneously) or placebo at weeks 0 and 26, plus standard care.
KASL clinical practice guidelines for noninvasive tests to assess liver fibrosis in chronic liver disease.
Clin Mol Hepatol
September 2024
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Author Correction: Elevated body temperature is associated with depressive symptoms: results from the TemPredict Study.
Sci Rep
April 2024
Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, San Diego, CA, USA.
Elevated body temperature is associated with depressive symptoms: results from the TemPredict Study.
Sci Rep
February 2024
Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, San Diego, CA, USA.
Article Synopsis
- The study investigates the relationship between body temperature and depression, hypothesizing that more severe depressive symptoms correlate with higher body temperature, smaller temperature differences between awake and asleep states, and lower temperature amplitude throughout the day.* -
- Using data from over 20,000 participants, the research found that both self-reported and wearable sensor data indicated higher body temperatures were linked to greater depression severity.* -
- While lower diurnal temperature amplitude also showed a trend towards being associated with higher depression severity, this result wasn’t statistically significant, suggesting that body temperature changes could be important in understanding and treating major depressive disorder.*
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