AI Article Synopsis
- Neuroborreliosis is an uncommon cause of cerebral vasculitis and stroke, but its incidence is rising in Finland, suggesting it could lead to more stroke cases in the future.
- A study at Helsinki University Hospital identified 10 cases of neuroborreliosis-related strokes or transient ischemic attacks (TIAs) among patients diagnosed with borreliosis between 2014 and 2019, with a low overall incidence.
- Despite the rarity of these conditions, patients generally had favorable outcomes when treated with antibiotics, although some may require additional immunosuppressive therapies.
Article Abstract
Objectives: Neuroborreliosis is a rare cause of cerebral vasculitis and stroke. The incidence of Lyme borreliosis in Finland has been increasing in the last 20 years, so we expect that Lyme neuroborreliosis-associated vasculitis can be a more common cause of stroke in the future.
Materials & Methods: We have retrospectively identified all adult patients (>16 years old) diagnosed with borreliosis (A69.2 Lyme borreliosis), transient ischemic attack (TIA, G45), and ischemic stroke (I63) at Helsinki University Hospital during 1.1.2014-31.10.2019 at our neurological emergency department. Medical data and follow-up data were retrospectively collected from medical records. Neuroborreliosis was diagnosed according to the European Federation of Neurological Societies guidelines.
Results: We have identified 10 cases of neuroborreliosis-associated stroke or TIA and/or vasculitis. Vasculitis as a manifestation of borreliosis was diagnosed in six patients of 1454 (0.4%) and stroke or TIA in nine (0.6%) of all borreliosis patients at Helsinki University Hospital. Clinical outcomes for all our patients were good with a modified Rankin scale (mRS) 0-2.
Conclusions: Lyme neuroborreliosis-associated vasculopathy and cerebrovascular events still remain rare but should be considered especially in Lyme borreliosis endemic areas. Prognosis is good with appropriate antibiotic treatment, but additional immunosupressive treatment is sometimes needed.
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| http://dx.doi.org/10.1016/j.jns.2021.117544 | DOI Listing |
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