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Nipah virus survey in of eastern and northeastern region of India, 2022-2023.
Front Microbiol
December 2024
Maximum Containment Facility, ICMR-National Institute of Virology, Pune, India.
Introduction: India has experienced seven outbreaks of the Nipah virus (NiV) since 2001, primarily occurring in the southern and eastern regions of the country. The southern region has been the main site for these outbreaks. In contrast, the eastern region, which borders Bangladesh, has not reported any outbreaks since 2007.
View Article and Find Full Text PDFMalaysia outbreak survivors retain detectable Nipah antibodies and memory B cells after 25 years.
J Infect
January 2025
Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia. Electronic address:
Objective: To evaluate the long-term humoral immune response to Nipah virus (NiV) in a cohort of 25 survivors after 25 years of post-infection.
Methods: A total of 25 survivors of NiV infection from the 1998 outbreak were recruited for sample collection. The serum IgG antibody response to NiV antigens, specifically nucleocapsid (N), fusion glycoprotein (F) and attachment glycoprotein (G) was evaluated using ELISA.
Expression of Toll-like Receptor Genes and Antiviral Cytokines in Macrophage-like Cells in Response to Indole-3-carboxylic Acid Derivative.
Viruses
October 2024
Faculty of Biotechnology, Lomonosov Moscow University of Fine Chemical Technology, Moscow 119571, Russia.
Article Synopsis
- Ongoing outbreaks of various viral infections highlight the urgent need for new antiviral compounds, with a focus on immunomodulatory drugs due to the immunotoxic properties of many viruses.
- A synthetic compound related to indole-3-carboxylic acid derivatives (referred to as XXV) has been developed, demonstrating antiviral and interferon-inducing activities in a macrophage-like cell model.
- The study utilized real-time PCR to show that XXV significantly stimulates the expression of toll-like receptors, interferons, and cytokines, indicating its role as an activator of innate immunity and its potential in fighting viral pathogens.
Strengthening Public Health Systems to Combat the Rising Threat of Nipah Virus: A Call for Global Preparedness and Response.
Adv Exp Med Biol
November 2024
Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India.
The chapter explores ways to increase global preparedness as well as reactions to the Nipah virus, which is a devastating zoonotic risk with serious health impacts. The Nipah virus is transmitted through bats and humans and poses major problems due to its high mortality rate, fast spread, and the absence of treatments or vaccines. The chapter argues for a holistic strategy incorporating the One Health framework to address human, animal, and environmental health interdependence.
View Article and Find Full Text PDFArticle Synopsis
- - The resurgence of Nipah virus (NiV) in Kerala poses significant public health challenges, highlighting the need for proactive strategies to prevent future outbreaks due to its zoonotic nature and changing transmission patterns.
- - Recent NiV outbreaks have presented atypical respiratory symptoms, complicating detection efforts, and emphasize the importance of regional surveillance and understanding the virus's new genotype.
- - A comprehensive approach involving early detection, public awareness, and strong collaboration between government and health organizations is necessary to manage the impact of NiV and ensure public safety through ongoing research.
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