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http://dx.doi.org/10.1164/rccm.202104-0836LE | DOI Listing |
Clin Med Insights Oncol
January 2025
Department of General Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Background: Serum Cystatin S (CST4), a secretory protein that inhibits cellular matrix degradation, significantly influences the tumor microenvironment and tumor progression. However, the prognostic value of serum CST4 in gastric cancer (GC) remains unclear. This study aims to explore serum CST4's utility in GC prognostic assessment.
View Article and Find Full Text PDFChem Sci
December 2024
Department of Chemistry, The Scripps Research Institute 10550N. Torrey Pines Road, La Jolla CA 92037 USA
Catalytic alkene isomerization is a powerful synthetic strategy for preparing valuable internal alkenes from simple feedstocks. The utility of olefin isomerization hinges on the ability to control both positional and stereoisomerism to access a single product among numerous potential isomers. Within base-metal catalysis, relatively little is known about how to modulate reactivity and selectivity with group 6 metal-catalyzed isomerization.
View Article and Find Full Text PDFImmunogenetics
January 2025
Laboratorio de Bioconservación y Manejo, Posgrado en Ciencias Químicobiológicas, Departamento de Zoología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación Carpio y Plan de Ayala S/N, Col. Santo Tomás, C.P. 11340, Ciudad de México, Mexico.
Unlike other mammals, bats serve as natural reservoirs for several highly pathogenic viruses without exhibiting symptoms of infection. Recent research has explored the complex mechanisms underlying the balance between bats' antiviral defenses and their pathological responses. However, the evolution of the molecular drivers behind bats' antiviral strategies remains largely unknown.
View Article and Find Full Text PDFDevelopment
January 2025
Department of Biology, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan.
Oscillatory dynamics and their modulation are crucial for cellular decision-making; however, analysing these dynamics remains challenging. Here, we present a tool that combines the light-activated adenylate cyclase mPAC with the cAMP biosensor Pink Flamindo, enabling precise manipulation and real-time monitoring of cAMP oscillation frequencies in Dictyostelium. High-frequency modulation of cAMP oscillations induced cell aggregation and multicellular formation, even at low cell densities, such as a few dozen cells.
View Article and Find Full Text PDFMikrochim Acta
January 2025
College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, 643000, P.R. China.
Cytosine-rich and poly(adenine)-tailed tetrahedral DNA framework (TDF) is designed as template (A-TDF) for anchoring silver nanoclusters (AgNCs) and igniting the dual-color fluorescence of AgNCs. The resultant DNA-AgNCs simultaneously emits red and green fluorescence, and the quantum yield of red fluorescence is as high as 44.8%.
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