Metabolic Syndrome and Related Inflammation, Prevalence, and Predictive Value of C-Reactive Protein in South Asian Youths.

Metabolic syndrome (MetS) is widely prevalent in the South Asian (SA) population. The syndrome leads to a high risk of premature atherosclerosis and diabetes. Obesity, specifically abdominal obesity, is a central pathological mechanism of disease in this population. Ethnic-specific modified measurements of waist circumference (WC) have been proposed for the diagnosis in various populations, including those of SA phenotype. We studied the prevalence of MetS and subclinical inflammation in young physically fit students in a major urban city of Pakistan. Specifically, we addressed the new lower WC measurement and its relationship with MetS and inflammation. C-reactive protein (CRP) was measured as a marker for subclinical inflammation. A total of 509 respondents (mean age 19.86 years) filled out self-administered questionnaires for data collection. Measurements were made by trained nurses using standardized equipment and fasting blood samples were drawn for chemical analysis. Data were verified, tabulated, and statistically analyzed. MetS was identified in 6% of this cohort and 16% had subclinical information as measured by CRP. Higher CRP levels were noted with higher WC and independently identified subjects with MetS. CRP levels of ≥2.2 mg/dL predicted presence of MetS. MetS is widely prevalent in young, otherwise physically fit, individuals. High proportion of this young cohort had evidence of subclinical inflammation as measured by CRP. Increasing WC showed significant correlation with higher CRP levels, level of 2.2 mg/dL independently identified MetS in this cohort.