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Nanomaterials-Enabled Sensors for Detecting and Monitoring Chemical Warfare Agents.
Small
December 2024
School of Chemical Engineering, University of New South Wales (UNSW Sydney), Sydney, New South Wales, 2052, Australia.
Despite their restrictions under international treaties, many chemical warfare agents (CWAs) and their toxic analogues are still used in various industrial sectors such as agriculture and chemical manufacturing. Thus, the need for sensitive and selective CWA detection remains critical. Commercially available detection methods, while accurate, are often bulky, expensive, and require specialized personnel.
View Article and Find Full Text PDFDupilumab, corticosteroids and their combination for the treatment of bullous pemphigoid.
An Bras Dermatol
December 2024
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China. Electronic address:
Background: Conventional systemic corticosteroid therapy for bullous pemphigoid (BP) has been challenged due to severe adverse events. Dupilumab has emerged as an alternative therapeutical option of BP patients.
Objectives: To evaluate the efficacy of dupilumab monotherapy and the combination with medium/low-dose corticosteroids for BP treatment.
Construction of an animal model of autism based on interaction between cerebellar histological, immunohistochemical, and biochemical changes in adult male albino rat.
Ultrastruct Pathol
December 2024
Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Methods: Twelve pregnant female rats were divided into a control group and a valproic acid (VPA) treated group (injected intraperitoneally on embryonic day 12 with 600 mg/kg body weight of VPA). Neurobehavioral tests were conducted on the offspring of both groups. The cerebellum was studied by light and electron microscopy as well as GFAP and caspase-3 immunohistochemical staining.
View Article and Find Full Text PDFActivating Esterase D by PFD5 exerts antiviral effect through inhibiting glutathionization of LAMP1 during Senecavirus A infection.
Microb Pathog
January 2025
Institute of Medical Science, The Second Hospital of Shandong University, Jinan, 250033, PR China. Electronic address:
Seneca virus A (SVA) is a newly discovered small nucleic acid virus, which can cause swine blister disease (PVD). Currently, there is no drug or vaccine. Studies have shown that SVA relies on the endolysosomal pathway to accomplish intracellular transport and release, and can disrupt lysosomal homeostasis, but its specific mechanism has not been revealed.
View Article and Find Full Text PDFComputational hemodynamic pathophysiology of internal carotid artery blister aneurysms.
Biomed Eng Online
November 2024
Division of Neurosurgery, Centre Hospitalier de L'Université de Montréal, Montréal, QC, Canada.
Objective: Blister aneurysms of the internal carotid artery (ICA) are rare and are primarily documented in the literature through small series and case reports. The intraoperative observation of a hemorrhage in the artery wall proximal to the aneurysmal bulge led to the hypothesis that some of these aneurysms might develop in a retrograde manner.
Methods: We developed software to reconstruct the ICA with and without Type I and II blister aneurysms using patients' imagery as input to simulate hemodynamic conditions before and after their formation.
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