A total of 12 new cycloartane- and lanostane-type triterpenoids including 16-deoxyargentatin A (), 16-deoxyisoargentatin A (), 7-oxoisoargentatin A (), 24--argentatin H (), 24---anisoylargentatin C (), 24---cinnamoylargentatin C (), 16-dehydroargentatin C (), 16,17(20)-didehydroargentatin C (), isoargentatin C (), isoargentatin H (), 3--quisquagenin (), and isoquisquagenin () together with 10 known triterpenoids (-) were isolated from the resin of AZ-2 obtained as a byproduct of Bridgestone guayule rubber production. The structures of new triterpenoids - and argentatin H (), which has previously been characterized as its diacetate (), were elucidated by extensive analysis of their spectroscopic data and chemical conversions, and the known compounds - were identified by comparison of their spectroscopic data with those reported. Of these, , , and exhibited weak cytotoxic activity for several cancer cell lines.
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