AI Article Synopsis
- The study aimed to investigate the link between skin lesions in children and SARS-CoV-2 infection, while also considering other possible infectious or autoimmune causes.
- Conducted between April and May 2020, the study involved 62 children with skin manifestations, diagnosing SARS-CoV-2 through PCR and serology tests.
- Results showed that those with positive antibodies to SARS-CoV-2 had a higher occurrence of chilblains and vesicular-bullous lesions, whereas generalized rashes were more frequent in those without antibodies, with other pathogens identified in many of the latter.
Article Abstract
Background: Cutaneous manifestations have been included in COVID-19 patients' clinical spectrum. Our objective was to determine the association between skin lesions in children and SARS-CoV2 infection, analyzing others possible infectious/autoimmune etiologies.
Material And Methods: Observational, multicenter, cross-sectional study, about children with skin manifestations from April to May 2020. The diagnosis of SARS-CoV2 was performed by PCR in nasopharyngeal exudate and/or presence of antibodies by serology.
Results: Sixty-two children were included, 9 (14.5%) presented positive antibodies to SARS-CoV-2, with no positive PCR to SARS-Cov-2 in those patients in whom it was made. Patients with positive serology to SARS-CoV-2 presented chilblains and/or vesicular-bullous skin lesions more frequently (66.7% vs. 24.5%, = 0.019). Generalized, urticarial and maculopapular rash was more common in patients with negative antibodies (37.7 vs. 0%, = 0.047), others pathogens were isolated in 41.5% of these patients. There were no significant differences in the positivity for autoantibodies between both groups.
Conclusion: In our study, the presence of chilblains-like and/or vesicular lesions were significantly related to SARS-CoV2 previous contact.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196301 | PMC |
| http://dx.doi.org/10.1016/j.medcle.2021.03.007 | DOI Listing |
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