Penile skin bridge stones are rare complications which has never been reported in literature hence information about management is non-existent. This case reports a 24-year-old man presenting with recurrent inflammatory symptoms in his sizeable penile skin bridge. Clinical examination revealed multiple calculi which was confirmed after surgical division of the SB. Phimosis and stone migration are the pathological basis underlying all reported cases of non-urethral calculi in uncircumcised elderly phallus. Extra-luminal urolithiasis in a young circumcised man, we believe have different predisposing factors and prognosis. Treatment involved stone removal and debridement of the skin bridge which yielded successful outcome.
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http://dx.doi.org/10.1016/j.eucr.2021.101742 | DOI Listing |
Cell Stem Cell
December 2024
Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, 17176 Stockholm, Sweden. Electronic address:
Wound healing is vital for human health, yet the details of cellular dynamics and coordination in human wound repair remain largely unexplored. To address this, we conducted single-cell multi-omics analyses on human skin wound tissues through inflammation, proliferation, and remodeling phases of wound repair from the same individuals, monitoring the cellular and molecular dynamics of human skin wound healing at an unprecedented spatiotemporal resolution. This singular roadmap reveals the cellular architecture of the wound margin and identifies FOSL1 as a critical driver of re-epithelialization.
View Article and Find Full Text PDFGeriatrics (Basel)
December 2024
Medicine for Older People, University Hospital Southampton, Tremona Road, Southampton SO16 6YD, UK.
The incidence of melanoma is increasing globally. The estimated worldwide incidence is projected to increase from 324,635 cases in 2020 to 510,000 in 2040. In the UK, melanoma accounts for 4% of all new cases of cancer.
View Article and Find Full Text PDFAm J Physiol Cell Physiol
December 2024
Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, California, USA.
The optimum length for force generation () increases as activation is reduced, challenging classic theories of muscle contraction. Although the activation dependence of is seemingly consistent with length-dependent Ca sensitivity, this mechanism can't explain the apparent force dependence of , or the effect of series compliance on activation-related shifts in . We have tested a theory proposing that the activation dependence of relates to force depression resulting from shortening against series elasticity.
View Article and Find Full Text PDFJ Am Acad Dermatol
December 2024
Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA 10016. Electronic address:
J Am Acad Dermatol
December 2024
Department of Dermatology, Weill Cornell Medicine, New York, NY, USA. Electronic address:
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