AI Article Synopsis
- Photoacoustic microscopy (PAM) is a noninvasive imaging technique that helps visualize the internal structures of living animals, but traditional PAM systems struggle with larger scanning areas.
- The researchers developed a new dual-channel PAM system with a custom slider-crank scanner, allowing for a wide scanning area of 24 mm and a fast B-scan speed of 32 Hz, maintaining high image quality.
- The system successfully imaged various biological specimens without contrast agents and demonstrated potential for monitoring blood flow with the use of magnetic contrast agents, highlighting its promise for biological research.
Article Abstract
Photoacoustic microscopy (PAM) is an important imaging tool that can noninvasively visualize the anatomical structure of living animals. However, the limited scanning area restricts traditional PAM systems for scanning a large animal. Here, we firstly report a dual-channel PAM system based on a custom-made slider-crank scanner. This novel scanner allows us to stably capture an ultra-widefield scanning area of 24 mm at a high B-scan speed of 32 Hz while maintaining a high signal-to-noise ratio. Our system's spatial resolution is measured at ∼3.4 μm and ∼37 μm for lateral and axial resolution, respectively. Without any contrast agent, a dragonfly wing, a nude mouse ear, an entire rat ear, and a portion of mouse sagittal are successfully imaged. Furthermore, for hemodynamic monitoring, the mimicking circulating tumor cells using magnetic contrast agent is rapidly captured . The experimental results demonstrated that our device is a promising tool for biological applications.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190471 | PMC |
| http://dx.doi.org/10.1016/j.pacs.2021.100274 | DOI Listing |
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