The effect and prognosis of combinative implantation by autologous-fat granule and prosthesis for breast reconstruction after radical mastectomy.

Objectives: In this study, we analyzed the effect and prognosis of combinative implantation of autologous-fat granule and prosthesis for breast reconstruction after radical mastectomy.

Methods: 73 cases of breast cancer patients hospitalized from March 2015 to March 2017 were chosen and separated into observation group (n=41) and control group (n=32) on the basis of the surgical methods. Both the two groups underwent modified radical mastectomy. In addition, the control group received prosthesis implantation for breast reconstruction, and the observation group was implanted with combination of prosthesis and autologous-fat granule transplantation. Thereafter, the surgical indexes, postoperative complications, aesthetic effects of breast reconstruction and prognosis of the two groups of patients were evaluated.

Results: The surgical duration of the observation group was obviously longer than that of the control group (), while the two groups had insignificant difference in postoperative drainage duration and postoperative hospital stay (). FACT-B score of both groups of patients one year after surgery was dramatically higher than that before surgery (), and patients in observation group had remarkably higher scores than those in control group (). The incidence of postoperative complications in observation group was substantially lower than that in control group (). In addition, the aesthetic evaluation of the observation-group patients postoperatively was notably higher than that in control group (), and there was no statistically significant difference in progression-free survival between the two groups ().

Conclusion: The combinative implantation of both prosthesis and autologous-fat granule for breast reconstruction after radical mastectomy is simple in operation procedure, and has better aesthetic outcome and safety. It satisfies the aesthetic demand of patients while having lesions resection, and does not affect the surgical effect of modified radical mastectomy, which is worthy of clinical promotion.