AI Article Synopsis
- New research shows that long non-coding RNA LINC01503 is found at higher levels in cervical cancer tissues, suggesting it plays a role in disease progression.
- Increased LINC01503 expression correlates with more advanced cancer stages, greater tumor metastasis to lymph nodes, and deeper tissue invasion.
- Inhibiting LINC01503 reduces tumor cell invasion and growth, and this effect is linked to its interaction with miR-615-3p, which regulates its expression.
Article Abstract
Mounting evidence indicates that long non-coding RNAs influence the progression of cervical cancer, but the precise function of LINC01503 in the pathogenesis of the disease remains unknown. Here, we found higher levels of LINC01503 in cervical cancer tissues. High LINC01503 expression was associated with enhanced progression of cervical cancer as indicated by advanced FIGO stage, increased metastasis of tumor cells to lymph nodes, and invasion into deeper cervical tissues. LINC01503 inhibition markedly suppressed the invasion and proliferative ability of tumor cells. Mechanistically, LINC01503 was demonstrated to negatively modulate the expression of miR-615-3p in cervical cancer. was found to be a target of miR-615-3p. Rescue experiments indicated that LINC01503 inhibition suppressed the invasion and proliferative ability of the tumor cells, a phenomenon that was reversed following miR-615-3p inhibition or overexpression. Collectively, these data indicate that LINC01503 enhances the progression of cervical cancer cells via interaction with miR-615-3p/ axis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210569 | PMC |
| http://dx.doi.org/10.7150/jca.54148 | DOI Listing |
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