By feeding tryptophan to the marine-derived fungus sp. HNMF114 from the bivalve mollusk , 3 new quinazoline-containing indole alkaloids, named aspertoryadins H-J (-), along with 16 known ones (-), were obtained. The structures of the new compounds were elucidated by the analysis of spectroscopic data combined with quantum chemical calculations of nuclear magnetic resonance (NMR) chemical shifts and electron capture detector (ECD) spectra. Structurally, compound represents the first example of this type of compound, bearing an amide group at C-3. Compounds and showed potent α-glucosidase inhibitory activity with IC values of 7.18 and 5.29 μM, and compounds and showed a clear activation effect on the ryanodine receptor from (sfRyR), which reduced the [Ca] by 37.1 and 36.2%, respectively.
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Three New Quinazoline-Containing Indole Alkaloids From the Marine-Derived Fungus sp. HNMF114.
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College of Life Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding, China.
By feeding tryptophan to the marine-derived fungus sp. HNMF114 from the bivalve mollusk , 3 new quinazoline-containing indole alkaloids, named aspertoryadins H-J (-), along with 16 known ones (-), were obtained. The structures of the new compounds were elucidated by the analysis of spectroscopic data combined with quantum chemical calculations of nuclear magnetic resonance (NMR) chemical shifts and electron capture detector (ECD) spectra.
View Article and Find Full Text PDFQuinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus sp. HNMF114.
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Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences , Haikou 571101 , People's Republic of China.
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