AI Article Synopsis
- - The use of animal models, especially rodents, has significantly advanced our understanding of substance use disorders (SUD) by exploring behavioral and molecular mechanisms related to addiction.
- - The IntelliCage is a new automated system designed to assess addiction-like traits in group-housed rodents by measuring behaviors like navigation, reward preference, and cognitive functions.
- - This innovative platform allows researchers to effectively monitor changes in behavior and cognition linked to substance addiction, making it a valuable tool for high-throughput screening in SUD research.
Article Abstract
The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211779 | PMC |
| http://dx.doi.org/10.3389/fnbeh.2021.683780 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!