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Tumor microenvironment-responsive multinucleated nanocomplexes loaded with carbon dots for combined photothermal/chemodynamic therapy of breast cancer.
ChemMedChem
January 2025
Peking University, No.38 Xueyuan Rd, 100191, Beijing, CHINA.
Low cure rate and high death rate of cancers have seriously threatened human health. The combining multiple therapies is a promising strategy for cancer treatment. In this study, we construct a novel multinucleated nanocomplex loaded with carbon dots (CDs-SA@TAMn) that responds to tumor microenvironment for combined photothermal/chemodynamic cancer therapy.
View Article and Find Full Text PDFLive-cell FRET assay on the stoichiometry and affinity of the YAP complexes in MCF-7 cells.
Arch Biochem Biophys
January 2025
Department of Pain Management, the First Affiliated Hospital of Jinan University, Guangzhou 510630, China. Electronic address:
Yes-associated protein (YAP), a focal point of current biological research, is involved in regulating various life processes. In this report, live-cell fluorescence resonance energy transfer (FRET) imaging was employed to unravel the YAP complexes in MCF-7 cells. Fluorescence imaging of living cells co-expressing CFP (cyan fluorescent protein)-YAP and YFP (yellow fluorescent protein)-LATS1 (large tumor suppressor 1) plasmids revealed that YAP promoted LATS1 oligomerization around mitochondria.
View Article and Find Full Text PDFSingle-Injection Composite Tracer Achieves Intraoperative Dual-Tracing and Precise Localization of Sentinel Lymph Nodes.
ACS Appl Mater Interfaces
January 2025
Sixth People's Hospital, School of Medicine & School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, P. R. China.
The use of dual-tracer contrast agents in clinical applications, such as sentinel lymph node (SLN) identification, offers significant advantages including enhanced accuracy, sensitivity, as well as comprehensive and multimodal visualization. In the current clinical practice, SLNs are typically marked prior to surgical resection by multiple and sequential injections of two tracers, the radioactive tracer and methylene blue (MB) dye. This imposes physical and psychological burden on patients and medical staff.
View Article and Find Full Text PDFMotion-less depth-selective optogenetic probe using tapered fiber and an electrically tuneable liquid crystal steering element.
Biomed Opt Express
January 2025
Center for Optics, Photonics and Lasers, Department of Physics, Engineering Physics and Optics, Université Laval, 2375 Rue de la Terrasse, Québec, Québec G1V 0A6, Canada.
A miniature electrically tuneable liquid crystal component is used to steer light from -1° to +1° and then to inject into a simple tapered fiber. This allows the generation of various propagation modes, their leakage, and selective illumination of the surrounding medium at different depth levels without using mechanical movements nor deformation. The performance of the device is characterized in a reference fluorescence medium (Rhodamine 6G) as well as in a mouse brain (medullary reticular formation and mesencephalic locomotor regions) during in-vivo experiments as a proof of concept.
View Article and Find Full Text PDFA gene-encoded bioprotein second harmonic generation (SHG) probe from Autographa californica nuclear polyhedrosis virus (AcMNPV) polyhedrin for live cell imaging.
Eur Biophys J
January 2025
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
Compared to fluorescence, second harmonic generation (SHG) has recently emerged as an excellent signal for imaging probes due to its unmatched advantages in terms of no photobleaching, no phototoxicity, no signal saturation, as well as the superior imaging accuracy with excellent avoidance of background noise. Existing SHG probes are constructed from heavy metals and are cellular exogenous, presenting with high cytotoxicity, difficult cellular uptake, and the limitation of non-heritability. We, therefore, initially propose an innovative gene-encoded bioprotein SHG probe derived from Autographa californica nuclear polyhedrosis virus (AcMNPV) polyhedrin.
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