AI Article Synopsis
- The study highlights a new imaging tool using a specific gold nanocluster (AuNC) that targets the CCR2 receptor, which helps monitor the development of atherosclerosis in mice.
- This imaging method allows for the early detection of atherosclerotic lesions and tracking the progression and regression of plaques effectively.
- The findings also suggest that CCR2 is a relevant biomarker for human atherosclerosis, indicating potential for the clinical use of this targeted imaging probe.
Article Abstract
The development of atherosclerosis therapy is hampered by the lack of molecular imaging tools to identify the relevant biomarkers and determine the dynamic variation in vivo. Here, we show that a chemokine receptor 2 (CCR2) targeted gold nanocluster conjugated with extracellular loop 1 inverso peptide (AuNC-ECL1i) determines the initiation, progression and regression of atherosclerosis in apolipoprotein E knock-out (ApoE) mouse models. The CCR2 targeted Cu-AuNC-ECL1i reveals sensitive detection of early atherosclerotic lesions and progression of plaques in ApoE mice. CCR2 targeting specificity was confirmed by the competitive receptor blocking studies. In a mouse model of aortic arch transplantation, Cu-AuNC-ECL1i accurately detects the regression of plaques. Human atherosclerotic tissues show high expression of CCR2 related to the status of the disease. This study confirms CCR2 as a useful marker for atherosclerosis and points to the potential of Cu-AuNC-ECL1i as a targeted molecular imaging probe for future clinical translation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8684599 | PMC |
| http://dx.doi.org/10.1016/j.nano.2021.102416 | DOI Listing |
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