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| http://dx.doi.org/10.1016/j.mycmed.2021.101161 | DOI Listing |
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Post-COVID Fungal Osteomyelitis-Another Killer.
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Department of Oral and Maxillofacial Surgery, Dasmesh Institute of Research and Dental Sciences, Faridkot, Punjab, India.
Article Synopsis
- - COVID-19, caused by the virus SARS-CoV-2, has become a global pandemic with significant health impacts.
- - Analysis of past SARS data suggests that fungal co-infections during the COVID-19 pandemic may often go unnoticed or incorrectly diagnosed.
- - The report includes case studies of patients who developed fungal infections in the maxilla and orbit after recovering from COVID-19, highlighting successful treatment and ongoing monitoring.
Invasive mucorales sinusitis in a young patient with Emberger syndrome and newly diagnosed AML: A case report and literature review of invasive fungal infections in GATA2 deficiency.
Mycoses
December 2023
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Centre, Houston, Texas, USA.
Germline pathogenic variants (PVs) in the gene encoding the GATA2 transcription factor can result in profound reductions of monocytes, dendritic cells, natural killer cells and B cells. GATA2 PVs are associated with an increased risk of myeloid malignancies and a predisposition to nontuberculous mycobacterial and human papillomavirus infections. Additionally, invasive fungal infections (IFIs) have been reported in individuals with GATA2 PVs, even in the absence of myeloid malignancies.
View Article and Find Full Text PDFDefective antifungal immunity in patients with COVID-19.
Front Immunol
December 2022
Public Health Wales, Microbiology Cardiff, Wales, United Kingdom.
The COVID-19 pandemic has placed a huge strain on global healthcare and been a significant cause of increased morbidity and mortality, particularly in at-risk populations. This disease attacks the respiratory systems and causes significant immune dysregulation in affected patients creating a perfect opportunity for the development of invasive fungal disease (IFD). COVID-19 infection can instill a significant, poorly regulated pro-inflammatory response.
View Article and Find Full Text PDFImmunopathology of COVID-19 and its implications in the development of rhino-orbital-cerebral mucormycosis: a major review.
Orbit
December 2022
Ophthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
Article Synopsis
- The literature review focuses on the immunopathological changes caused by COVID-19 and their possible link to the development of rhino-orbital-cerebral mucormycosis (ROCM).
- COVID-19 disrupts respiratory epithelial integrity, compromises immune function, and creates a favorable environment for Mucorales fungal invasion due to various factors, including hyperglycemia and immune cell dysfunction.
- The findings suggest that COVID-19 facilitates ROCM development through mechanisms affecting the respiratory mucosa and impairing both innate and adaptive immunity, alongside promoting conditions like iron overload.
A Vaccine Construction against COVID-19-Associated Mucormycosis Contrived with Immunoinformatics-Based Scavenging of Potential Mucoralean Epitopes.
Vaccines (Basel)
April 2022
Department of Surgical, Oncological and Stomatological Disciplines, University of Palermo, 90133 Palermo, Italy.
Mucormycosis is a group of infections, caused by multiple fungal species, which affect many human organs and is lethal in immunocompromised patients. During the COVID-19 pandemic, the current wave of mucormycosis is a challenge to medical professionals as its effects are multiplied because of the severity of COVID-19 infection. The variant of concern, Omicron, has been linked to fatal mucormycosis infections in the US and Asia.
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