A chemoselective and robust protocol for the γ-oxidation of β,γ-unsaturated amides is reported. In this method, electrophilic amide activation, in a rare application to unsaturated amides, enables a regioselective reaction with TEMPO resulting in the title products. Radical cyclisation reactions and oxidation of the synthesised products highlight the synthetic utility of the products obtained.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8456850 | PMC |
| http://dx.doi.org/10.1002/anie.202104023 | DOI Listing |
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