AI Article Synopsis
- Adolescent onset idiopathic nephrotic syndrome (INS) shows higher occurrences of atypical features and non-minimal change disease in histopathology compared to other age groups.
- The study was conducted at a pediatric nephrology clinic in North India, evaluating 33 adolescents diagnosed with idiopathic nephrotic syndrome.
- Key findings included that 70% had steroid-resistant nephrotic syndrome, with symptoms like hematuria in 39%, hypertension in 36%, and acute kidney injury in 27%, while most biopsies revealed non-minimal change disease.
Article Abstract
Adolescent onset idiopathic nephrotic syndrome (INS) is marked by increased incidence atypical features and non-minimal change disease in histopathology. The objective of the study was to analyze the clinical features and histopathological spectrum of adolescent-onset INS. It was conducted in a Pediatric nephrology clinic of a tertiary care hospital in North India. We retrospectively evaluated clinical features, biochemical investigations and histopathology of 33 adolescents with idiopathic NS registered in pediatric nephrology clinic. Twenty-three (70.0%) adolescents had steroid resistant nephrotic syndrome. Hematuria was present in 39%, hypertension 36% and acute kidney injury (AKI) in 27%. Three-fourth of adolescents who underwent biopsy had non-minimal change disease in histopathology. Adolescent onset INS have increased incidence of AKI, hypertension, and non-minimal change disease.
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| http://dx.doi.org/10.4103/1319-2442.318525 | DOI Listing |
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