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Multiparametric grading of glaucoma severity by histopathology can enable post-mortem substratification of disease state.
Acta Neuropathol Commun
January 2025
Ophthalmology, Novartis Biomedical Research, Cambridge, MA, USA.
Neurodegeneration in glaucoma patients is clinically identified through longitudinal assessment of structure-function changes, including intraocular pressure, cup-to-disc ratios from fundus images, and optical coherence tomography imaging of the retinal nerve fiber layer. Use of human post-mortem ocular tissue for basic research is rising in the glaucoma field, yet there are challenges in assessing disease stage and severity, since tissue donations with informed consent are often unaccompanied by detailed pre-mortem clinical information. Further, the interpretation of disease severity based solely on anatomical and morphological assessments by histology can be affected by differences in death-to-preservation time and tissue processing.
View Article and Find Full Text PDFImaging and management of complications post biliary-enteric anastomosis.
Abdom Radiol (NY)
January 2025
University of Virginia, Charlottesville, USA.
Biliary-enteric anastomosis is a common surgical procedure for benign and malignant pathologies involving bile ducts, pancreas and duodenum, as well as during liver transplantation. Imaging is key in detecting potential complications. Ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and nuclear scintigraphy provide complementary information.
View Article and Find Full Text PDFThe cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation.
Alzheimers Res Ther
January 2025
Functional Imaging Unit, Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Valdemar Hansens Vej 1-23, Glostrup, 2600, Denmark.
Background: Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer's Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, the exact mechanisms are not known.
View Article and Find Full Text PDFPD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD).
J Transl Med
January 2025
Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Background: Non-Small Cell Lung Cancer (NSCLC) is the leading cause of cancer death worldwide. Although immune checkpoint inhibitors (ICIs) have shown remarkable clinical efficacy, they can also induce a paradoxical cancer acceleration, known as hyperprogressive disease (HPD), whose causative mechanisms are still unclear.
Methods: This study investigated the mechanisms of ICI resistance in an HPD-NSCLC model.
Classification of cervical cancer using Dense CapsNet with Seg-UNet and denoising autoencoders.
Sci Rep
December 2024
Decisions LAB, Department of Law, Economics and Human Sciences, University Mediterranea of Reggio Calabria, Via dei Bianchi, 2, 89131, Reggio Calabria, Italy.
Cervical cancer is one of the deadly diseases that affects women, which requires periodic examinations to identify and treat any cancerous tumors at a preliminary stage. The most prevalent examination tool for cervical cancer prompt identification is the cervical smear (Pap smear) testing; however, due to human negligence, this examination method has an elevated probability of negative findings. Cervical cancer classification using machine learning (ML) and deep learning (DL) has been extensively studied to enhance the conventional diagnostic process.
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