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L. aerial parts: anti-proliferative evaluation on human tumour and non-tumour cell lines. | LitMetric
Bearing in mind the several medicinal properties of genus, this work aimed to evaluate the anti-proliferative potential of the ethanolic extract (EE) and fractions from L aerial parts. Using the anti-proliferative protocol developed by the NCI/USA, four fractions (F2 - F4 and F6) obtained from EE showed promising anti-proliferative profile against a panel of human tumor and non-tumor cell lines. After 24-h exposure, F2 (0.25 µg/mL) showed potent and irreversible anti-proliferative effect without inducing cell cycle arrest in both NCI-H460 and MCF-7 cells, without (anti) estrogenic activity. These effects were lost after storage of F2 diluted in dimethyl sulfoxide at -80 °C during 2 weeks. Analysis by gas chromatography coupled to mass detection evidenced some chemical changes induced by F2 storage in solution. The present study demonstrated the anti-proliferative effect of . Further studies are necessary to determine better storage conditions to enhance F2 stability.
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