[Middle-molecule spectrum of the blood serum in patients with a continuously progressive paranoid form of schizophrenia undergoing treatment].

Screening and gel filtration on Sephadex G-15 (Pharmacia, Sweden) were used to study mean molecular (MM) components (the level of total fraction and spectrum) in the serum of patients suffering from continuously progressing paranoid schizophrenia. The findings evidenced elevated level of the fraction and rearranged spectrum of the components. MM components 5 significant increase and peaks I decrease registered in the study may play a role in pathogenesis of the disease and underlie the development of its productive symptoms.