AI Article Synopsis
- FBD may be linked to reduced enzyme activity, particularly disaccharidases, which could improve diagnosis and treatment if identified early.
- A study of 82 FBD patients found high rates of deficiencies in lactase (86.5%), maltase (48.7%), sucrase (50%), and glucoamylase (84.1%), with many showing reduced overall enzyme activity.
- Results indicated that 95.2% of patients had low enzyme function related to carbohydrate digestion, suggesting a strong connection between disaccharidase deficiency and gastrointestinal symptoms in FBD.
Article Abstract
Background: Functional bowel disorder (FBD) may be caused by a decrease in disaccharidase activity. Thus, the timely diagnosis of disaccharidase deficiency could lead to a better prognosis in patients with this condition.
Aim: To determine the potential value of intestinal disaccharidases glucoamylase, maltase, sucrase, and lactase in understanding the etiology and pathogenesis of FBD.
Methods: A total of 82 FBD patients were examined. According to the Rome IV criteria (2016), 23 patients had diarrhea-predominant irritable bowel syndrome (IBS), 33 had functional diarrhea, 10 had constipation-predominant IBS, 4 had functional constipation, and 12 had mixed IBS. The Dahlqvist method was used to measure disaccharidase activity in the brush-border membrane of mature enterocytes of the small intestine, in duodenal biopsies obtained during esophagogastroduodenoscopy.
Results: Lactase deficiency was detected in 86.5% of patients, maltase deficiency in 48.7%, sucrase deficiency in 50%, and glucoamylase deficiency in 84.1%. The activities of all enzymes were reduced in 31.7% of patients, and carbohydrase deficiency was detected in 63.5% of patients. The low activity of enzymes involved in membrane digestion in the small intestine was found in 95.2% of patients.
Conclusion: In 78 of the 82 patients with FBD, gastrointestinal symptoms were associated with disaccharidase deficiency.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173401 | PMC |
| http://dx.doi.org/10.12998/wjcc.v9.i17.4178 | DOI Listing |
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