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Drug-induced Hyperprolactinemia Results in Atypical Atypical Fracture. | LitMetric

Drug-induced Hyperprolactinemia Results in Atypical Atypical Fracture.

Hip Pelvis

Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Published: June 2021

AI Article Synopsis

  • A 43-year-old woman experienced bilateral femur fractures, possibly linked to long-term use of antipsychotic medications.
  • Imaging tests showed a complete fracture in the right femur and an incomplete fracture in the left, both in the subtrochanteric area, and she was treated with intramedullary nailing.
  • Laboratory results indicated hyperprolactinemia and hypogonadism, highlighting a connection between antipsychotic drugs, increased prolactin levels, and the risk of osteoporosis, warranting further investigation and MRI for patients with similar symptoms.

Article Abstract

We report a case of bilateral femur fracture which may have resulted in part from long-term administration of antipsychotic agents. A 43-year-old female patient with pain in both thighs visited our clinic. We conducted X-ray and magnetic resonance imaging (MRI) examinations which revealed bilateral femur fractures. The right proximal femur had a complete fracture, and the left proximal femur had an incomplete fracture, both of which were in the subtrochanteric area. The patient was treated by intramedullary nailing in the right femur. Laboratory analysis showed hyperprolactinemia and hypogonadism. Bone mineral density analysis showed osteoporosis. Antipsychotic drug-induced hyperprolactinemia is a well-known phenomenon. Despite concerns about hyperprolactinemia induced osteoporotic fracture in patients treated with only prolactin-elevating medications, the issue has not been extensively studied. If hyperprolactinemia patients suffer from uncontrolled pain, we recommend MRI examination as surgeons should be aware of the possibility of osteoporotic fracture induced by hyperprolactinemia.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190499PMC
http://dx.doi.org/10.5371/hp.2021.33.2.102DOI Listing

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