AI Article Synopsis
- The uterus is crucial for embryo implantation and fetal growth, but most current research focuses on later pregnancy stages to improve outcomes for premature births.
- There is a need for in vitro (lab-based) models that concentrate on uterine tissue to better understand diseases like endometriosis and uterine cancers, as well as the process of embryo implantation.
- The text suggests the possibility of creating stem cell-based models of the uterus using techniques like microfluidics and 3D printing to explore these important issues.
Article Abstract
The uterus is the organ for embryo implantation and fetal development. Most current models of the uterus are centred around capturing its function during later stages of pregnancy to increase the survival in pre-term births. However, in vitro models focusing on the uterine tissue itself would allow modelling of pathologies including endometriosis and uterine cancers, and open new avenues to investigate embryo implantation and human development. Motivated by these key questions, we discuss how stem cell-based uteri may be engineered from constituent cell parts, either as advanced self-organising cultures, or by controlled assembly through microfluidic and print-based technologies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211708 | PMC |
| http://dx.doi.org/10.1038/s42003-021-02233-8 | DOI Listing |
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