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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497765 | PMC |
| http://dx.doi.org/10.4046/trd.2021.0063 | DOI Listing |
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The Macklin Effect Following Trauma: A Case Report of Concurrent Pneumothorax, Pneumoperitoneum, Pneumomediastinum, and Pneumoretroperitoneum in an Intubated Young Adult.
Cureus
December 2024
Department of Trauma Surgery, King Saud Medical City, Riyadh, SAU.
Article Synopsis
- Pneumomediastinum, often occurring silently post-trauma, complicates diagnoses especially when paired with other conditions like pneumothorax and pneumoperitoneum, largely due to the Macklin effect where air escapes from ruptured alveoli.
- An 18-year-old male involved in a car crash was found with severe pneumothorax and subcutaneous emphysema but showed no signs of significant esophageal or bronchial injury upon further evaluation.
- Despite alarming initial imaging, the patient's treatment was conservative, allowing for a gradual healing process and eventual discharge without complications, illustrating the need for careful assessment in trauma management.
Macklin effect: Spontaneous pneumomediastinum caused by marijuana.
Natl Med J India
January 2024
Department of Thoracic Surgery, Hospital Clinico Universitario De Valladolid, Avenida Ramón Y Cajal, Valladolid, España-Spain.
Spontaneous Pneumomediastinum in a Patient with Marijuana Use.
Eur J Case Rep Intern Med
September 2024
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.
Unlabelled: The Macklin effect plays an essential role in the pathogenesis of spontaneous pneumomediastinum. It is the process by which is there is a blunt alveolar rupture that leads to air dissection through the bronchopulmonary sheaths and spreads into the mediastinum. Theoretically, marijuana use can cause spontaneous pneumomediastinum indirectly by inducing rigorous vomiting.
View Article and Find Full Text PDFPneumomediastinum.
Thorac Surg Clin
November 2024
Department of Thoracic Surgery, Creighton University Medical Center, Omaha, NE, USA. Electronic address:
Pneumomediastinum, air within the mediastinum, is the manifestation of a variety of causes including those that are benign and some resulting in severe morbidity and even mortality. This article reviews the epidemiology, etiology, and pathophysiology of pneumomediastinum as an independent pathologic and physiologic entity, as well as reviews the workup and management of those patients who are diagnosed with pneumomediastinum.
View Article and Find Full Text PDFExtracorporeal membrane oxygenation for prevention of barotrauma in patients with respiratory failure: A scoping review.
Artif Organs
February 2025
Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Article Synopsis
- Barotrauma is a common issue in patients with severe respiratory failure, often leading to bad outcomes, but ECMO (Extracorporeal Membrane Oxygenation) may help reduce this risk through lung-protective ventilation.
- A review of studies found that ECMO was used in 45 patients, with 46.7% receiving it before invasive ventilation; it allowed for safer ventilation strategies in many cases.
- The incidence of barotrauma was under 10% among these patients, and overall mortality was 17.8%, suggesting that ECMO can be a viable option to prevent barotrauma in respiratory failure.
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