The front cover artwork front cover artwork is provided by NMRCoRe, the Flemish NMR/X-Ray platform for Convergence Research and was designed by Ir. Ewoud Vaneeckhaute and Dr. Eric Breynaert. The image shows the reciprocity between parahydrogen, deuterated ammonia and iridium allowing for hyperpolarized 2D NMR via long-term availability of longitudinal spin order. Read the full text of the Article at 10.1002/cphc.202100079.
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http://dx.doi.org/10.1002/cphc.202100360 | DOI Listing |
J Neurol Sci
December 2024
Computational and Translational Neuroscience Laboratory, Institute of Cognitive Sciences and Technologies, National Research Council (CTNLab-ISTC-CNR), Via Gian Domenico Romagnosi 18A, Rome 00196, Italy; AI2Life s.r.l., Innovative Start-Up, ISTC-CNR Spin-Off, Via Sebino 32, Rome 00199, Italy. Electronic address:
Alzheimer's disease (AD), the most common neurodegenerative disorder world-wide, presents sex-specific differences in its manifestation and progression, necessitating personalized diagnostic approaches. Current procedures are often costly and invasive, lacking consideration of sex-based differences. This study introduces an explainable machine learning (ML) system to predict and differentiate the progression of AD based on sex, using non-invasive, easily collectible predictors such as neuropsychological test scores and sociodemographic data, enabling its application in every day clinical settings.
View Article and Find Full Text PDFSchizophrenia (Heidelb)
December 2024
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
PET and SPECT studies in treatment-resistant schizophrenia (TRS) have revealed significant alterations in regional cerebral blood flow (CBF) during clozapine treatment, which may vary according to the clinical response. Here, we used the more recent MRI approach of arterial spin labelling (ASL) to evaluate regional CBF in participants with TRS (N = 36) before starting treatment with clozapine compared to in healthy volunteers (N = 16). We then compared CBF in the TRS group, before and after 12 weeks of treatment with clozapine (N = 24); and examined the relationship of those differences against changes in Positive and Negative Syndrome Scale for Schizophrenia (PANSS) scores over the treatment period.
View Article and Find Full Text PDFSci Adv
December 2024
Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China.
Optical spin and orbital angular momenta are intrinsic characteristics of light determined by its polarization and spatial degrees of freedom, respectively. At the nanoscale, sharply focused structured light carries coupled spin-orbital angular momenta with complex 3D nearfield structures, crucial for manipulating multidimensional information of light in nanophotonics. However, characterizing these interactions faces challenges with conventional farfield-based methods, which typically lack the essential accuracy and resolution to interrogate the structured nearfield with high fidelity.
View Article and Find Full Text PDFPhys Chem Chem Phys
December 2024
Universite de Lyon, CNRS, UCB Lyon1, Institut des Sciences Analytiques, UMR5280, Villeurbanne, France.
The emergence of very high NMR magnetic fields will certainly encourage the study of larger biological systems with their dynamics and interactions. NMR spin relaxation allows probing the dynamical properties of proteins where the N longitudinal () and transverse () relaxation rates in addition to the H-N heteronuclear NOE describe the ps-ns time scale. Their analytical representation involves the chemical shift anisotropy (CSA) effect that represents the major contribution at a very high magnetic field above 18.
View Article and Find Full Text PDFNanophotonics
April 2024
National Key Laboratory of Optical Field Manipulation Science and Technology, Chinese Academy of Sciences, Chengdu 610209, China.
The manipulation of vector optical fields in three-dimensional (3D) space plays a vital role in both fundamental research and practical implementations of polarization optics. However, existing studies mostly focus on 3D vector optical fields with limited modes. Here, an approach of spin-decoupled spatial partitioning is proposed to generate complex 3D vector optical fields with a customizable number of modes on demand.
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