Background: The proximal fascia lata (FL) graft construct used for arthroscopic superior capsule reconstruction (ASCR) is openly harvested, whereas the mid-thigh FL graft construct is minimally invasively harvested. The purpose of the current study was to compare the biomechanical properties of proximal thigh and mid-thigh-harvested FL graft constructs used for ASCR. The hypothesis was that, despite the different morphological characteristics of the proximal thigh and mid-thigh FL graft constructs used for ASCR, their biomechanical properties would not significantly differ. This information may assist orthopedic surgeons in the choice of the harvest location, technique, and type of graft construct for ASCR.
Methods: Forty FL specimens, 20 proximal thigh and 20 mid-thigh, were harvested from the lateral thighs of 10 fresh human cadavers (6 male, 4 female; average age, 58.60 ± 17.20 years). The thickness of each 2-layered proximal thigh and 6-layered mid-thigh FL graft construct was measured. Each construct was mechanically tested in the longitudinal direction, and the stiffness and Young's modulus were computed. Data were compared by Welch's independent t-test and analysis of variance, and statistical significance was set at < .05.
Results: The average thickness of the proximal thigh FL graft construct (7.17 ± 1.97 mm) was significantly higher than that of the mid-thigh (5.54 ± 1.37 mm) [F (1,32) = 7.333, = .011]. The average Young's modulus of the proximal thigh and mid-thigh graft constructs was 32.85 ± 19.54 MPa (range, 7.94 - 75.14 MPa; 95% confidence interval [CI], 23.71 - 42.99) and 44.02 ± 31.29 MPa (range, 12.53 -120.33 MPa; 95% CI, 29.38 - 58.66), respectively. The average stiffness of the proximal thigh and mid-thigh graft constructs was 488.96 ± 267.80 N/mm (range, 152.96 - 1086.49 N/mm; 95% CI, 363.63 - 614.30) and 562.39 ± 294.76 N/mm (range, 77.46 - 1229.68 N/mm; 95% CI, 424.44 - 700.34), respectively. There was no significant difference in the average Young's modulus or stiffness between the proximal thigh and mid-thigh graft constructs ( = .185 and = .415, respectively).
Conclusion: Despite the different morphological characteristics of the proximal thigh and mid-thigh FL graft constructs used for ASCR, their Young's modulus and stiffness did not significantly differ.
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http://dx.doi.org/10.1016/j.jseint.2021.01.016 | DOI Listing |
Gels
November 2024
Laboratory of Nanochemistry, Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó Street 37-47, H-1094 Budapest, Hungary.
Hydrogel membranes can offer a cutting-edge solution for abdominal hernia treatment. By combining favorable mechanical parameters, tissue integration, and the potential for targeted drug delivery, hydrogels are a promising alternative therapeutic option. The current review examines the application of hydrogel materials composed of synthetic and biological polymers, such as polyethylene glycol (PEG), polyvinyl alcohol (PVA), gelatine, and silk fibroin, in the context of hernia repair.
View Article and Find Full Text PDFIran J Kidney Dis
December 2024
Department of Urology, Maoming People's Hospital, Maoming, China.
Introduction: Autophagy related genes (ARGs) may play important roles in various biological processes involving kidney transplantation (KT); however, their expression characteristics are rarely used to study the relationship between autophagy and prognosis in KT patients. This study aims to construct a new autophagy related gene feature based on high-throughput sequencing datasets.
Methods: Differentially expressed ARGs (DEARGs) were identified in KT patients based on the Gene Expression Omnibus (GEO) database.
Front Surg
December 2024
Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Institute for Precision Medicine, Tsinghua University, Beijing, China.
Background: Intraoperative hemorrhage is one of the major complications of orthotopic liver transplantation (OLT) and is mainly caused by technical difficulties of the surgical procedure besides primary liver diseases. The present study aimed to evaluate the feasibility and clinical effects of a novel proceduralized donor liver back-table preparation (DLBTP) technique for use in OLT.
Methods: This retrospective study was conducted between January 2018 and June 2020 based on patients who had undergone OLT.
J Nanobiotechnology
December 2024
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, JS, 226001, P. R. China.
Peripheral nerve injury poses a significant challenge to the nervous system's regenerative capacity. We previously described a novel approach to construct a chitosan/silk fibroin nerve graft with skin-derived precursor-induced Schwann cells (SKP-SCs). This graft has been shown to promote sciatic nerve regeneration and functional restoration to a level comparable to that achieved by autologous nerve grafts, as evidenced by behavioral, histological, and electrophysiological assessments.
View Article and Find Full Text PDFColloids Surf B Biointerfaces
December 2024
Key Laboratory of Macromolecular Synthesis and Functionalization (Ministry of Education), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China; Center of Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing 312000, China. Electronic address:
Polymethacrylate and its derivatives are widely used in food industry and biomedical applications for their plasticity, biocompatibility and optical transparency. However, susceptibility to bacterial growth on their surfaces limits their applications. In this study, linear and branched polyethyleneimine (PEI) molecules were grafted onto poly(ethyl methacrylate) (PEMA) via aminolysis using a simple one-step method to enhance the antibacterial properties of PEMA films.
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