AI Article Synopsis
- - The study analyzed the occurrence and effects of superinfections in COVID-19 patients with acute respiratory distress syndrome in an ICU setting, finding that 57.6% of patients had at least one superinfection during their stay.
- - Ventilator-associated pneumonia was the most common, with bacteria like K. pneumoniae and P. aeruginosa being significant culprits, while bloodstream infections and fungal infections were also reported.
- - Key factors that increased the risk of ICU or 28-day mortality included the presence of bacterial infections, older age, and a higher Sequential Organ Failure Assessment score.
Article Abstract
Unlabelled: To describe the epidemiology of superinfections (occurring > 48 hr after hospital admission) and their impact on the ICU and 28-day mortality in patients with coronavirus disease 2019 with acute respiratory distress syndrome, requiring mechanical ventilation.
Design: Retrospective analysis of prospectively collected observational data.
Setting: University-affiliated adult ICU.
Patients: Ninety-two coronavirus disease 2019 patients admitted to the ICU from February 21, 2020, to May 6, 2020.
Interventions: None.
Measurements And Main Results: The prevalence of superinfection at ICU admission was 21.7%, and 53 patients (57.6%) had at least one superinfection during ICU stay, with a total of 75 (82%) ventilator-associated pneumonia and 57 (62%) systemic infections. The most common pathogens responsible for ventilator-associated pneumonia were ( = 26, 34.7%) and ( = 14, 18.7%). Bloodstream infection occurred in 16 cases, including methicillin-resistant ( = 8, 14.0%), species ( = 6, 10.5%), and species ( = 2, 3.5%). Fungal infections occurred in 41 cases, including 36 probable (30 by , six by ) and five proven invasive candidiasis (three , two ). Presence of bacterial infections (odds ratio, 10.53; 95% CI, 2.31-63.42; = 0.005), age (odds ratio, 1.17; 95% CI, 1.07-1.31; = 0.001), and the highest Sequential Organ Failure Assessment score (odds ratio, 1.27; 95% CI, 1.06-1.63; = 0.032) were independently associated with ICU or 28-day mortality.
Conclusions: Prevalence of superinfections in coronavirus disease 2019 patients requiring mechanical ventilation was high in this series, and bacterial superinfections were independently associated with ICU or 28-day mortality (whichever comes first).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202543 | PMC |
| http://dx.doi.org/10.1097/CCE.0000000000000430 | DOI Listing |
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