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Genotoxicity and cytotoxicity evaluation of two thallium compounds using the wing somatic mutation and recombination test. | LitMetric

Genotoxicity and cytotoxicity evaluation of two thallium compounds using the wing somatic mutation and recombination test.

Heliyon

Unidad de Investigación en Genética y Toxicología Ambiental, Unidad Multidisciplinaria de Investigación Experimental (UMIE-Z), FES Zaragoza, Campus II, UNAM, Iztapalapa, C.P. 15000, CdMx, Mexico.

Published: May 2021

AI Article Synopsis

Article Abstract

Thallium (Tl) is a heavy and toxic metal and a byproduct of several human activities, such as cement production, mining, and coal combustion. Thallium is found in fruits, vegetables, and animal fodder with high Tl contamination; therefore, it is an environmental pollution issue and a toxicological contamination problem for human beings and other organisms when exposed to it. The mutagenic potential of Tl and its compounds is controversial, and there are few studies on its effects. We conducted the animal bioassay wing somatic mutation and recombination test (SMART) to test for genotoxicity and assessed the genotoxic effects of Tl acetate (TlCHCOO) and Tl sulfate (TlSO) on . Third instar larvae from the SMART standard cross (ST) were fed Tl acetate [0.2, 2, 20, 200, 600 and 1200 μM] and Tl sulfate [0.2, 2, 20, 200, and 600 μM]. Hexavalent chromium [CrO, 500 μM] served as the positive control, and Milli-Q water served as the negative control. Only the high TlSO [600 μM] concentration resulted in genotoxicity with 87.6% somatic recombination, and both salts disrupted cell division of wing imaginal disc cells, showing the expected cytotoxic effects. Genotoxic risks due to high metal levels by bioaccumulation of Tl or its compounds require further evaluation with other and assays.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176319PMC
http://dx.doi.org/10.1016/j.heliyon.2021.e07087DOI Listing

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