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Article Synopsis
- The study investigates the fractional exhaled nitric oxide (FeNO) levels in a healthy population to better understand normal ranges and their influencing factors.
- FeNO levels were measured in 2,251 participants aged 6-82 years, revealing median values that increase with age and vary based on gender, height, and eosinophil counts.
- The findings establish reference ranges for FeNO that can aid in clinical asthma diagnosis and management.
CTSS contributes to airway neutrophilic inflammation in mixed granulocytic asthma.
Respir Res
December 2024
Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Background: Mixed granulocytic asthma (MGA) is usually associated with poor response to corticosteroid therapy and a high risk of severe asthma. Cathepsin S (CTSS) has been found to play an important role in various inflammatory diseases. This study was aimed to investigate the role of CTSS in MGA.
View Article and Find Full Text PDFRespiratory failure in a patient with exhaled nitric oxide >300 ppb and subsequent response to dupilumab.
Proc (Bayl Univ Med Cent)
August 2024
North Texas Allergy and Asthma Associates and Division of Allergy/Immunology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA.
Multiple biologic agents are approved for the treatment of severe persistent asthma not controlled by inhaled corticosteroid/beta-agonist therapy. Appropriate phenotyping can aid in picking the right biologic for the right patient. Here is a unique case of a patient with severe asthma and respiratory arrest, with fraction of exhaled nitric oxide >300 ppb whose asthma became completely controlled with dupilumab.
View Article and Find Full Text PDFEffects of physical exercise on cardio-respiratory health of young adults during short-term exposure to varying air pollution levels.
BMC Public Health
December 2024
School of Exercise and Health, Shanghai University of Sport, Yangpu District Qingyuan Huan Road 650, Shanghai, 200438, China.
Background: Air pollution (AP) has become a substantial environmental issue affecting human cardiorespiratory health. Physical exercise (PE) is widely accepted to promote cardiorespiratory health. There is a paucity of research on the point at which the level of polluted environment engaged in PE could be used as a preventive approach to compensate for the damages of AP.
View Article and Find Full Text PDFAssessing the utility of fractional exhaled nitric oxide-guided management in adult patients with asthma: A systematic review and meta-analysis.
Respir Investig
January 2025
Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan.
Background: Fractional exhaled nitric oxide (FeNO) has been utilized as a reliable biomarker for diagnosis, treatment response, and prediction of future risks in asthma care, that potentially ensures the efficacy of FeNO-guided asthma management. As previous systematic reviews reported limited efficacy with this approach, we evaluated the efficacy of FeNO-guided management in monitoring adults with asthma.
Methods: In this systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Review and Meta-Analyses Statement and the Minds Manual for Guideline Development, we updated a Cochrane systematic review in 2016 by adding six papers reporting randomized controlled trials with a treatment duration ≥12 weeks published between June 2016 and July 2022, and conducted a sub-analysis of two groups stratified by the strategy used: the FeNO-alone and FeNO with symptom score groups.
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