Novel halogenated flame retardants (HFRs) were introduced to industrial markets as alternatives to legacy brominated FRs (BFRs), such as polybrominated diphenyl ethers (PBDEs). In the present study, PBDEs and their brominated and chlorinated alternatives, novel BFRs (NBFRs) and dechlorane plus (DP), were measured in multiple environmental matrices in a highly industrialized lake in Korea. Legacy and novel HFRs were detected in multiple samples, indicating ubiquitous contamination. Concentrations of HFRs in water and sediment observed in creeks running through machine, textiles, and automobile industrial complexes were significantly higher than those observed in inside and outside of the lake. Higher bioaccumulation levels of HFRs were observed in inshore compared with offshore waters. Results suggest that multi-matrix distribution of legacy and novel HFRs was dependent on the geographical proximity to industrial sources. Compared with previous studies, the highest levels of PBDEs and NBFRs were recorded in water samples on a global scale, implying on-going emissions from industrial activities. Decabromodiphenyl ethane (DBDPE) was a dominant compound in water samples, whereas the concentrations of PBDEs, NBFRs, and DP in sediment were similar to each other. This suggests a shift in consumption from legacy to novel HFRs, preferentially in water environments. A significant declining trend in PBDEs was observed in water and sediment collected between 2008 and 2015, indicating the effectiveness of regulatory actions. Based on their environmental occurrence and bioaccumulation potential, pentabromoethylbenzene and bis(2-ethylhexyl) tetrabromophthalate may pose emerging concerns regarding contamination of aquatic environments.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.chemosphere.2021.130620 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis of a di-O-acylated deoxynojirimycin (DNJ) derivative and evaluation of its antibacterial and antibiofilm activity against Staphylococcus aureus and Stenotrophomonas maltophilia.
Carbohydr Res
January 2025
Department of Chemical Sciences, University of Naples Federico II, Naples, I-80126, Italy.
Herein we report the synthesis of a novel di-O-acylated DNJ derivative, conceived to study whether iminosugar derivatization with a lipophilic acyl moiety could positively affect its antibacterial properties. The well-known PS-TPP/I/ImH activating system was used to readily install the acyl chains on the iminosugar, leading to the desired compound in high yield. Biological assays revealed that a di-O-lauroyl DNJ derivative enhanced the antibacterial effect of gentamicin and amikacin against S.
View Article and Find Full Text PDFGlucose Supplementation Enhances the Bactericidal Effect of Penicillin and Gentamicin on Persisters.
Antibiotics (Basel)
January 2025
Division of Infections and Molecular Biology, Department of Health Promotion, Kyushu Dental University, Kitakyushu 803-8580, Fukuoka, Japan.
: is a leading cause of infective endocarditis (IE), which causes diverse clinical symptoms and even death. Recurrence after treatment is a crucial problem in IE, possibly caused by the presence of "persister" cells, a small bacterial population that can survive antimicrobials. In this study, the residual risk for penicillin G (PCG) and gentamicin (GM), used for treating IE, to induce persisters, was investigated.
View Article and Find Full Text PDFA new approach for assessing the radioecological risk associated with the legacy discharge of oil derived natural radioactivity in the UK North Sea.
Mar Pollut Bull
January 2025
School of Life Sciences, University of Essex, Colchester CO4 3SQ, UK.
Although oil and gas (O&G) derived produced waters and drill cuttings are known to contain enhanced levels of naturally occurring radium-228 (Ra) and radium-226 (Ra), most relevant ecological impact assessments have excluded radiological hazards and focus on other important contaminants, such as hydrocarbons and metals. Also, due to restricted access to the delimiting safety zone around operational O&G platforms, the few previous radioecological risk assessment studies have been conducted using seawater samples collected far from the main discharge point and applying default dilution and transfer factors to estimate concentrations of contaminants in biota. In this case study, sediment cores were collected close to a former O&G platform, Northwest Hutton (NWH), that used to be in the UK North Sea (61.
View Article and Find Full Text PDFEmergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion.
PLoS Biol
January 2025
RNA Virus Replication Laboratory, The Francis Crick Institute, London, United Kingdom.
Coronaviruses express their structural and accessory genes via a set of subgenomic RNAs, whose synthesis is directed by transcription regulatory sequences (TRSs) in the 5' genomic leader and upstream of each body open reading frame. In SARS-CoV-2, the TRS has the consensus AAACGAAC; upon searching for emergence of this motif in the global SARS-CoV-2 sequences, we find that it evolves frequently, especially in the 3' end of the genome. We show well-supported examples upstream of the Spike gene-within the nsp16 coding region of ORF1b-which is expressed during human infection, and upstream of the canonical Envelope gene TRS, both of which have evolved convergently in multiple lineages.
View Article and Find Full Text PDFA Novel Computational Machine Learning Pipeline to Quantify Similarities in Three-Dimensional Protein Structures.
Toxicol Sci
January 2025
Janssen Research & Development, LLC, La Jolla, California.
Animal models are widely used during drug development. The selection of suitable animal model relies on various factors such as target biology, animal resource availability and legacy species. It is imperative that the selected animal species exhibit the highest resemblance to human, in terms of target biology as well as the similarity in the target protein.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!