A novel norditerpenoid, sinusiaetone A (), featuring an uncommon bicyclo[11.3.0]hexadecane carbon skeleton, and four polyoxygenated cembranoids () were isolated from the Hainan soft coral . Their structures were established by spectroscopic analysis, X-ray diffraction, quantum chemical computational approaches, and/or a modified Mosher's method. A plausible biosynthetic pathway of and its biogenetic relationship with were proposed. New compounds displayed an interesting inhibitory activity against lipopolysaccharide-induced inflammation in BV-2 microglial cells.
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